KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
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چکیده
منابع مشابه
KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
Cancer cells that express oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival, but the molecular basis of this oncogene dependency remains incompletely understood. To identify genes that can functionally substitute for oncogenic RAS, we systematically expressed 15,294 open reading frames in a human KRAS-dependent colon cancer cell line engineered to...
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ژورنال
عنوان ژورنال: Cell
سال: 2014
ISSN: 0092-8674
DOI: 10.1016/j.cell.2014.06.004